An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
The human host response to monkeypox infection: a proteomic case series studyArticle Published on 2022-11-082022-11-16 Journal: EMBO Molecular Medicine [Category] 유전자 메커니즘, [키워드] acute phase response Applying Biomarker case sery CFHR1 complement correlation COVID-19 disease severity Diseases endemic area healthy controls Host host response human host Infection Monkeypox virus outbreak overlap Patient plasma plasma protein Protein Proteins proteome proteomic proteomics provided Research similarities suggested suppressed the disease viral infection Viral infection. [DOI] 10.15252/emmm.202216643 PMC 바로가기
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE studyArticle Published on 2022-11-012022-11-15 Journal: Angiogenesis [Category] 바이오마커, 유전자 메커니즘, [키워드] 28-day mortality adult COVID-19 patients Analysis Bacterial Bacterial sepsis Biomarker clinical outcomes Clinical severity Cluster Cohort conditions coronavirus disease Correlation analysis COVID-19 COVID-19 patient dimension disease disease entity dysfunction endothelial Endothelial dysfunction explained Health healthy control high mortality Hospitalized hospitals host response impairment independent intubation marker Microcirculation Microscopy Microvascular dysfunction microvascular injury outcome analysis outcomes overlap patients plasma plasma protein predict predictor Protein proteome proteomic Proteomic signature proteomics quantified sepsis. Variation was performed was used were measured were used [DOI] 10.1007/s10456-022-09843-8 PMC 바로가기
A prediction model for COVID-19 liver dysfunction in patients with normal hepatic biochemical parametersArticle Published on 2022-10-192022-11-16 Journal: Life Science Alliance [Category] 유전자 메커니즘, [키워드] Accuracy ALT Analysis AST benefit biochemical parameter Biochemical parameters Biomarker clinical variable Cohort Coronavirus disease 2019 COVID-19 COVID-19 patient Critical disease exhibit exhibited high risk identify independent limitation liver dysfunction machine learning model Patient performed predict proteomic serum sample Sex therapeutic strategy [DOI] 10.26508/lsa.202201576 PMC 바로가기
Rational Design and Development of SARS-CoV-2 Serological Diagnostics by Immunoprecipitation-Targeted ProteomicsArticle Published on 2022-09-272022-11-15 Journal: Analytical Chemistry [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] anti-RBD anti-SARS-CoV-2 antibody approach Combination convalescent convalescent plasma COVID-19 cross-reactivity current Cutoff detect development diagnostic Diseases domain elevated facilitate highest human immunoglobulin IgA IgA2 IGD IgE IgG IgG1 IgG2 IgG3 IgG4 IgM immune response immunoassay Immunoglobulin include isotype lack limit of detection limitation offer plasma Protein proteomic proteomics quantification Saliva SARS-CoV-2 serological Serological assay serological test serum significantly Simultaneous Standardization suggested [DOI] 10.1021/acs.analchem.2c01325 PMC 바로가기
CXCL8, CCL2, and CMV Seropositivity as New Prognostic Factors for a Severe COVID-19 CourseArticle Published on 2022-09-262022-11-15 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, 진단, [키워드] C4BPA C5aR1 CCL2 CCL3 CCR1 CFD chemokine chemokines CMV CMV status complement complement system. component Concentration contribute correlated Course courses COVID-19 COVID-19 patient CR1 CXCL10 CXCL8 Cytokine storm enrolled examined Factor groups healthy control Hyperinflammatory response ICU mechanisms molecular mRNA mRNA expression New non-ICU non-ICU patients pathogenesis and development pathophysiology plasma profile Prognostic factor protein level proteomic reduced Research SARS-CoV-2 Seropositivity severe COVID-19 significant difference time intervals [DOI] 10.3390/ijms231911338 PMC 바로가기
Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s diseaseArticle Published on 2022-09-232022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] AD-high-risk scores Alzheimer’s disease Astrocyte Cell cell population cognitive Cognitive impairment COVID-19 COVID-19 patients demonstrated disease disease-associated dysfunction GWAS identify mechanism Neuroinflammation Neuron neuronal pathway proteomic reported reveal RNA sequencing RNA-sequencing SARS-CoV-2 SARS-COV-2 infection single-nucleus RNA sequencing. subtype synaptic syndrome target therapeutic intervention transcriptomic [DOI] 10.3389/fimmu.2022.967356 PMC 바로가기
SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signalingArticle Published on 2022-09-132022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] activate Activation acute respiratory syndrome bortezomib caused contribute coronavirus COVID-19 patients cytokine Host identify IL-6 IL-8 IMPDH2 Infection inhibitor Interaction knockdown lung tissue sample mechanism mycophenolic acid NF-κB NF-κB activation NF-κB signaling nsp14 nuclear translocation occurred p65 pro-inflammatory cytokines promote Protein proteomic regulate ribavirin ribavirin. SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection the SARS-CoV-2 upregulation viral infection viral replication [DOI] 10.3389/fimmu.2022.1007089 PMC 바로가기
Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine CandidatesArticle Published on 2022-09-132022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Affect Amino acid association candidate cellular immunity change changed composed coronavirus COVID-19 creating Delta Epidemic immune immune responses immunized mice Inactivated vaccine Inactivated Vaccines induce induced metabolic metabolism metabolomic metabolomics mice neutralizing antibody positive profile Protein proteomic proteomics response resulting SARS-CoV-2 Vaccine vaccine candidates Vaccine design Vaccines Vaccines. variant variants Variation virus [DOI] 10.3390/ijms231810644 PMC 바로가기
Correlates with Vaccine Protective Capacity and COVID-19 Disease Symptoms Identified by Serum Proteomics in Vaccinated IndividualsArticle Published on 2022-09-132022-11-15 Journal: Molecules [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Algorithm allergy Analysis Asymptomatic autoantibodies autoantibody biological processes Biomarker Capacity caused characterized circulating Cohort coronavirus coronavirus disease correlated COVID-19 disease disease severity disease-associated effective intervention Efficacy epitope Evidence Genetic HBV Identified Immunoglobulin immunology implementation individual individuals mechanism non-severe cases pandemic PCR-negative PCR-positive PCR-positive individual profile Protective Protein Proteins proteomic proteomics purpura Quantitative RBD reducing response to vaccination risk SARS-CoV-2 severe disease severe symptom spike receptor-binding domain Symptom thrombosis understanding uninfected vaccinated individual Vaccine Vaccine development vaccine. virus transmission virus variant viruses with COVID-19 [DOI] 10.3390/molecules27185933 PMC 바로가기